Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC JTP10-△-TATi TFA | 99.7% | 2833.28 | 5 MG
JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor that exhibits 10-fold selectivity for JNK2 over JNK1 and JNK3. It has an IC50 of 92 nM for JNK2 and can inhibit the migration of PyVMTjnk2+/+ cells.
- Selective JNK2 peptide inhibitor
- IC50 of 92 nM for JNK2
- 10-fold selectivity over JNK1 and JNK3
- Inhibits migration of PyVMTjnk2+/+ cells
Medchemexpress LLC Charybdotoxin TFA | 96.8% | 4295.89 (free acid) | 100 UG
Charybdotoxin TFA is a 37-amino acid peptide that functions as a potassium channel blocker. This compound is a valuable tool for research involving potassium channels.
- Acts as a potassium channel blocker
- 37-amino acid peptide
- Useful for studying potassium channels
- Storage conditions for powder: -80°C for 2 years, -20°C for 1 year
- Storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month
- Sealed storage, away from moisture and light required for both forms
![Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate | 1336913-03-1 | 99.9% | 404.38 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438811-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate | 1336913-03-1 | 99.9% | 404.38 | 25 MG
PSEM 89S TFA is a selective and brain penetrant agonist for ion channels, orthogonally selective for Q79G and L141F. It is intended for research use only.
- Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance.
- Reversibly silences transfected neurons by reducing cellular input resistance.
- Reduces photostimulation-evoked feeding in mice with PSAML141F,Y115F-glycine receptor.
- Demonstrates good brain penetrance in mice after intraperitoneal administration.
- Suppresses fos in ChR2-expressing neurons in Agrp-cre mice.
- Shows rapid rise in serum and brain, cleared within 1 hour in C57BL/6 mice.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride
REAGENT Trifluoroacetic anhydride
Medchemexpress LLC MC-VC-PAB-NH2 trifluoroacetic acid | 1616727-21-9 | 99.9% | C33H47F3N8O10 | 10MG
MC-VC-PAB-NH2 TFA is a cleavable ADC linker supplied as the trifluoroacetic acid salt for research use. It contains a Val-Cit-PAB cleavable spacer designed for protease-triggered drug release and is provided as a white to off-white solid with high purity.
- Provides a protease-cleavable Val-Cit-PAB spacer for controlled payload release.
- Supplied as a TFA salt to aid handling and stability.
- High purity (≈99.9%) suitable for conjugation workflows.
- Soluble in DMSO at high concentration (100 mg/mL) with ultrasonic assistance.
- Solid, white to off-white appearance for convenient storage and handling.
- Storage recommendations: sealed, away from moisture and light; in solvent: -80°C (6 months), -20°C (1 month).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC ALX-1393 TFA | 949164-09-4 | 99.8% | 509.45 | 50 MG
ALX-1393 TFA is a selective glycine transporter-2 (GlyT2) inhibitor that demonstrates an antinociceptive effect, meaning it helps reduce pain. This compound has been observed to alleviate pain responses to thermal, mechanical, and chemical stimulations in a rat acute pain model. In experimental settings, administration of the compound has been shown to suppress the late-phase response in the formalin test and inhibit mechanical and cold hyperalgesia in a dose-dependent manner, without affecting motor performance in normal rats.
- Selectively inhibits a specific neuronal transporter.
- Exhibits pain-reducing effects across various types of pain stimuli.
- Effective in inflammatory and neuropathic pain models.
- Does not impair motor function.
TARGETMOL CHEMICALS INC CYN 154806 TFA 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. CYN 154806 TFA is a cyclic octapeptide and an effective selective somatostatin sst2 receptor antagonist. For the recombinant sst2, sst1, sst3, sst4 and sst5 receptors, the pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48, respectively. Purity 99.7%
Medchemexpress LLC L-lysine, L-lysyl-L-glutaminyl-L-phenylalanyl- | 99.6% | 891.73 | 5 MG
KQFK TFA is an inactive control peptide, supplied as the TFA salt form. This compound, with a molecular formula of C32H46F9N7O12 and a molecular weight of 891.73, presents as a white to off-white solid with a purity of 99.6%. It is intended for research use only.
- Inactive control peptide, TFA salt form
- White to off-white solid appearance
- High purity of 99.6%
- Powder can be stored for 2 years at -80°C or 1 year at -20°C in sealed conditions, away from moisture
- In solvent, stable for 6 months at -80°C or 1 month at -20°C with sealed storage, away from moisture
![Medchemexpress LLC (2S)-2-amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acid; TFA | 00-00-0 | 99.8% | 509.45 g·mol⁻¹ | C25H23F4NO6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000263712.png-250.jpg)
Medchemexpress LLC (2S)-2-amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acid; TFA | 00-00-0 | 99.8% | 509.45 g·mol⁻¹ | C25H23F4NO6 | 5 MG
ALX-1393 TFA is the trifluoroacetate salt of a selective glycine transporter 2 (GlyT2) inhibitor used as a research reagent to investigate glycinergic neurotransmission and nociception. It is supplied as a purified solid for laboratory use and has reported antinociceptive activity in rodent pain models.
- Selective GlyT2 inhibitor for probing glycinergic neurotransmission.
- Research-grade solid suitable for in vitro and in vivo studies.
- High purity (99.83%) supporting reproducible results.
- Molecular formula C25H23F4NO6 and molecular weight 509.45 g·mol⁻¹.
- Store at -20°C to maintain stability and minimize moisture exposure.
Medchemexpress LLC Diprotin A TFA | 209248-71-5 | 99.6% | 455.47 | 50 MG
Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) for research use only. It increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions. In in vivo models, it has been shown to increase retinal vascularity and leakage, and aggravate vascular leakage in diabetic retinopathy by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
- Inhibits dipeptidyl peptidase IV (DPP-IV).
- Increases phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells.
- Disrupts endothelial cell-to-cell junctions.
- Induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
Medchemexpress LLC FTO-IN-1 TFA | 2797619-81-7 | 98.1% | 505.27 | 1 ML
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32. It can be used for the research of cancer and is for research use only.
- FTO inhibitor with an IC50 of <1 μM
- Inhibits FTO enzyme activity by 62% in vitro at 50 μM
- Inhibits the viability of SCLC-21H, RH30 and KP3 cells with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively
Medchemexpress LLC 5A2-SC8 TFA | 1857341-90-2 | 98.6% | C93H173N5O20S5.xC2HF3O2 | 1 MG
5A2-SC8 TFA is an ionizable amino lipid utilized in lipid nanoparticles (LNPs), demonstrating significant potential for drug delivery with low in vivo toxicity. It facilitates the efficient delivery of small RNAs, such as siRNA and miRNA, specifically into tumor cells. This compound's LNPs can uniquely influence the delivery fate of RNA within the liver, thereby improving therapeutic outcomes in various cancer models.
- High delivery potential.
- Low in vivo toxicity.
- Enables efficient delivery of small RNAs (siRNA and miRNA) into tumor cells.
- Can alter therapeutic outcomes in cancer models by influencing RNA delivery in the liver.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC), 76-05-1, MFCD00004169
Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC)
Medchemexpress LLC OS-2966 10mg | 10mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC Gallinamide A TFA | 1352920-57-0 | 706.79 | 1 MG
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by inhibiting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum (IC50: 50 nM). It is for research use only and not sold to patients.
- Inhibits cathepsin L, B, V, K, and S.
- Effective against SARS-CoV-2 infection.
- Inhibits P. falciparum.
- Exhibits low cytotoxicity in VeroE6 cells.
- Shows synergistic effects with TMPRSS2 inhibitor Nafamostat.